Research Fellow (Cancer Science Institute of Singapore, Dr Lee Seungjae's lab)

Job Title: Research Fellow (Cancer Science Institute of Singapore, Dr Lee Seungjae's lab) University-Level Unit: Cancer Science Institute of Singapore Faculty/Department-Level Unit: Research Employee Category: Research Staff Location_ONB: Kent Ridge Campus Posting Start Date: 23/09/2026 About the Lab

The Lee Lab, led by Assistant Professor Seungjae (Jae) Lee, invites applications for postdoctoral researcher positions at the Cancer Science Institute of Singapore (CSI), National University of Singapore (NUS).

The Lee Lab investigates the emerging interface between RNA biology and cellular metabolism . We are particularly interested in understanding how metabolites, metabolic enzymes, and cellular metabolic states influence RNA structure, processing, translation, localisation, and function.

Our research combines functional genomics, molecular and cellular biology, biochemistry, chemical biology, high-throughput screening, and emerging RNA technologies to uncover previously unrecognised mechanisms connecting RNA regulation with cellular metabolism. A major long-term goal is to determine how these mechanisms can be exploited to enhance RNA therapeutics and uncover new vulnerabilities in cancer and other diseases.

For more information about our research and the Lee Lab, please visit sleelab.com .

The Position

We are looking for highly motivated and creative postdoctoral researchers who are excited to develop independent research projects in RNA biology and RNA-metabolism crosstalk.

Potential research directions include:

• Molecular mechanisms connecting cellular metabolism with RNA regulation
• Small RNA pathways, including miRNA, siRNA, and RNA interference
• RNA-binding proteins and post-transcriptional gene regulation
• Metabolite-RNA and metabolite-protein interactions
• Functional genomics and high-throughput genetic or chemical screening
• Development of new strategies to improve RNA therapeutics
• RNA regulatory mechanisms in cancer and other disease contexts

Postdoctoral researchers will have substantial freedom to develop their own scientific questions within the broad interests of the lab. We particularly encourage researchers who enjoy following unexpected observations, exploring unconventional ideas, and developing new experimental approaches.

Candidate Profile

Applicants should have, or expect to receive, a Ph.D. in molecular biology, biochemistry, genetics, cancer biology, chemical biology, computational biology, or a related field.

Experience in RNA biology is welcome but not required . Candidates with complementary expertise who are interested in applying their background to new questions in RNA biology and metabolism are strongly encouraged to apply.

We value scientific curiosity, creativity, independence, collaboration, and a willingness to explore ambitious questions.

Research Environment

The Lee Lab is located at the Cancer Science Institute of Singapore (CSI), National University of Singapore , providing access to a highly collaborative and interdisciplinary research environment, advanced core facilities, and the broader biomedical research community across NUS and Singapore.

Singapore also offers an international, English-speaking research environment in a vibrant and multicultural Asian city. NUS/CSI provides competitive postdoctoral compensation, with specific terms determined based on qualifications and experience.

How to Apply

Please send the following to Dr. Seungjae Lee at [email protected]:

• CV
• Brief statement describing your research experience, interests, and motivation
• Contact information for 2–3 referees

Positions are available from March 2027 onward , with applications considered on a rolling basis.

For questions or informal inquiries about the position, please feel free to contact Dr. Lee.